May 15, 2018: Improved Instrument Robustness via a Hot Surface Induced Desolvation (HSID) Interface for Tandem Mass Spectrometry Instrumentation: cannabis, pesticides and veterinary drug residue analysis
ANACHEM – The Association of Analytical Chemists and American Chemical Society – Detroit Local Section – Younger Chemists Committee Presents:
Improved Instrument Robustness via a Hot Surface Induced Desolvation (HSID) Interface for Tandem Mass Spectrometry Instrumentation: cannabis, pesticides and veterinary drug residue analysis
Traffic Jam & Snug, 511 West Canfield Street, Detroit, MI 48201
Tuesday, May 15, 2018 at 7 PM
Join us before the talk at 6:00 PM for a dutch-treat dinner
Presented by: Frank A. Kero, Ph.D., PerkinElmer Environmental Health, Downers Grove, IL
Abstract: The emergence of liquid chromatography tandem mass spectrometry (LC-MS/MS) as a gold standard analytical platform for quantitative method development in high throughput toxicology, environmental surveillance and food safety laboratories has been well documented. Recent trends in practical considerations for improvements towards laboratory implementation focus on reduced downtime to facilitate testing methods for large sample populations. This talk will report on related strategies with a special focus on a dual spray ionization apparatus equipped with a heated coaxial flow ion source. The result yields a path for ion introduction into the orifice of the mass spectrometer using multi-orthogonal channels and laminar flow sampling. The advantages for this platform include high sensitivity due to an inherent reduction in chemical background (i.e. S/N, reduced N). Instrument ruggedness and stability are also improved due to orthogonal sampling and laminar flow. The laminar flow phenomenon is achieved by a combination of the influences of gas flow dynamics and electric fields. Ions are orthogonally extracted at atmospheric pressure and focused through a series of channels and turns entrained in a hot laminar flow of gas (different than traditional mass spectrometry instrumentation). Efficient desolvation is accomplished as a result of sequential energy transfer events. The flow of gas evolves through multiple transitions beginning with supersonic transitioning to shock cascading to turbulent and decreasing to laminar flow. The reduction in the speed of ion transmission is important to maintaining the sensitivity advantages of this interface. Applications will demonstrate improved performance for residue analysis (pesticide, antibiotics, vet med drugs) in food and biological matrices.
Bio: Frank Kero is a field application scientist for PerkinElmer who has covered the Midwest, West, Northeast and Canadian territories. He holds a B.S in chemistry (Seton Hall University) and a Ph.D. in analytical chemistry (University of Florida). He was awarded an ORISE research fellowship at the Centers for Disease Control and Prevention where he completed work in support of NHANES and additional research evaluating the utility of animal sentinels for utility in exposure assessment of thyroid inhibitors in environmental surface waters. He has ~18 years analytical method development experience.
Brewing Chemistry is a monthly lectures series. These informal talks are designed to make science fun and accessible for all. The lectures take place at 7 p.m. on the third Tuesday of every month at:Traffic Jam & Snug, 511 West Canfield Street, Detroit, MI 48201.
There is no admission charge, and free parking is available.
For more information, contact Meghann at 313.993.1259 or firstname.lastname@example.org