November 12th, 2019: Tour of Kaiser Optical Systems
Join ANACHEM & ACS for a tour and a talk at Kaiser Optical Systems, Inc.!
Tuesday, November 12th, 2019
6:00 pm – Refreshments
6:30 pm – Tour of Kaiser Optical Systems
6:45 pm – Talk
Kaiser Optical Systems, Inc.
371 Parkland Plaza
Ann Arbor, MI 48103
Joint Meeting with Detroit ACS and SAS
Authors: Karen A. Esmonde-White, Sean Gilliam, Maryann Cuellar, Dave Strachan, Ian R.Lewis
As a process analytical technology, Raman spectroscopy is a powerful tool that provides real-time in situ measurements that inform on the process chemistry. Representative sampling of the process is an important aspect of ensuring a robust method, as incomplete sampling or sub-sampling may not adequately capture variations in the process. Solids and turbid media exhibit optical scattering, which affects the sampling volume of an optical probe and recovery of Raman-scattered photons. New approaches in sampling for Raman spectroscopy provide representative sampling in solids and turbid media and enable in-process corrections. Backscattered Raman, wide-area (or large volumetric) Raman, and enhanced reflection Raman are compatible with in-process measurements. Transmission Raman is a powerful off-line tool for measuring chemical heterogeneity within a solid or turbid sample. In a representative example we discuss how a hybrid approach using backscattered Raman and wide area Raman can provide multi-scale measurements in-process in order to improve understanding of a heterogeneous polymerization reaction. Similar examples in pharmaceutical and bioprocessing will illustrate Raman’s capability for providing robust measurements in process.
Contact Meghann at firstname.lastname@example.org or 313-993-1259 to RSVP