October 25th, 2017: Karen A. Esmonde-White — Tour and a Talk at Kaiser Optical Systems
Join us for a tour and a talk at Kaiser Optical Systems, Inc.!
Speaker: Karen A. Esmonde-White
Kaiser Optical Systems, Inc.
Wednesday, October 25th, 2017
6:30 pm – Refreshments
7:00 pm – Tour of Kaiser Optical Systems
7:15 pm – Talk
Kaiser Optical systems, Inc.
371 Parkland Plaza
Ann Arbor, MI 48103
Joint Meeting With Detroit-ACS and Detroit-SAS
Authors: Karen A. Esmonde-White1, Francis Esmonde-White1, Carsten Uerpmann2, Sean Gilliam1, Maryann Cuellar1, Ian R.Lewis1
1 Kaiser Optical Systems, Inc., 371 Parkland Plaza, 48103, Ann Arbor, USA
2 Kaiser Optical Systems, SARL, 5 Allee du moulin Berger, 69130, Ecully, France
As a process analytical technology, Raman spectroscopy is a powerful tool that provides real-time in situ measurements that inform on the process chemistry. Representative sampling of the process is an important aspect of ensuring a robust method, as incomplete sampling or sub-sampling may not adequately capture variations in the process. Solids and turbid media exhibit optical scattering, which affects the sampling volume of an optical probe and recovery of Raman-scattered photons. New approaches in sampling for Raman spectroscopy provide representative sampling in solids and turbid media and enable in-process corrections. Backscattered Raman, wide-area (or large volumetric) Raman, and enhanced reflection Raman are compatible with in-process measurements. Transmission Raman is a powerful off-line tool for measuring chemical heterogeneity within a solid or turbid sample. In a representative example we discuss how a hybrid approach using backscattered Raman and wide area Raman can provide multi-scale measurements in-process in order to improve understanding of a heterogeneous polymerization reaction. Similar examples in pharmaceutical and bioprocessing will illustrate Raman’s capability for providing robust measurements in process.